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The FDA Just Approved a Long-Lasting Injection to Prevent HIV

Spluk.ph by Spluk.ph
June 20, 2025
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The FDA Just Approved a Long-Lasting Injection to Prevent HIV
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The US Meals and Drug Administration has simply accepted lenacapavir, an injectable type of HIV prevention that’s virtually 100% efficient and requires solely two doses per 12 months. Science journal described the medication the most important scientific advance of 2024.

In scientific trials, lenacapavir proved to be 99.9 % efficient in stopping HIV an infection by way of sexual transmission in folks weighing greater than 35 kilograms. The drug, an antiretroviral, works not by stimulating an immune response, however by blocking HIV from reproducing throughout its early levels—particularly, by disrupting the operate of the virus’s capsid protein. This occurs as long as the physique receives injections each six months.

Lenacapavir has already been accepted in some nations as a therapy for HIV in folks with types of the virus which might be proof against different therapies. Nevertheless, previous to this week, its prophylactic use had not been accepted wherever, making the FDA’s determination a big new growth within the battle in opposition to the HIV/AIDS epidemic.

The drug is just not the primary drugs that may be taken preemptively to guard in opposition to an HIV an infection: pre-exposure prophylaxis (PrEP) drugs have been already accessible in lots of nations, together with america. However these should be taken every single day, and guaranteeing ongoing entry to those medicines, and that folks truly bear in mind to take them, is a known challenge. It’s hoped the long-lasting results of lenacapavir will make it simpler for folks to remain protected in opposition to the virus.

In accordance with its creator, Gilead Sciences, lenacapavir shall be marketed beneath the commerce identify Yeztugo. The corporate has dedicated to manufacturing 10 million doses by 2026.

“It is a historic day within the decades-long battle in opposition to HIV. Yeztugo is without doubt one of the most necessary scientific breakthroughs of our time and provides a really actual alternative to assist finish the HIV epidemic,” Daniel O’Day, president and CEO of Gilead, mentioned in a statement on Wednesday.

Nevertheless, lenacapavir’s worth could also be a barrier to entry. Yeztugo could have an annual record worth of $28,218 per particular person within the US. Winnie Byanyima, government director of of the Joint United Nations Program on HIV/AIDS (UNAIDS), has additionally flagged in the past that the drug is unaffordable for many individuals in Africa, the place the medication has the potential to have the most important impression. Roughly two-thirds of the folks residing with HIV worldwide stay in sub-Saharan Africa.

Gilead mentioned in a statement last year that it had been “creating a method to allow broad, sustainable entry globally” to lenacapavir, though the corporate has not but supplied detailed info on the way it will do that. One choice could possibly be “voluntary licensing,” the place different corporations are granted permission to supply and promote generic variations of a patented product solely to folks in sure (usually low-income) nations. Researchers on the College of Liverpool within the UK have calculated {that a} 12 months’s price of lenacapavir could possibly be made accessible for as little as $25.

This story initially appeared on WIRED en Español and has been translated from Spanish.



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